Assay Detail
Binding
CHEMBL4765711
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GAL4 fused TrkA (unknown origin) expressed in PC12 cells transfected with pFA2-Elk plasmid and pFR-luciferase plasmid measured for 18 hrs by luciferase reporter gene assay
24
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indole-like Trk receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.07 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457614 | — | — | 2 | 9.59 |
| CHEMBL104519 | — | — | 2 | 8.00 |
| CHEMBL104333 | — | — | 2 | 7.88 |
| CHEMBL104279 | — | — | 2 | 7.43 |
| CHEMBL322153 | — | — | 2 | 7.34 |
| CHEMBL4798255 | — | — | 2 | 7.03 |
| CHEMBL106226 | — | — | 2 | 6.99 |
| CHEMBL321955 | — | — | 2 | 6.47 |
| CHEMBL4788922 | — | — | 2 | 6.44 |
| CHEMBL4074055 | — | — | 2 | 6.05 |
| CHEMBL471375 | — | — | 2 | 6.00 |
| CHEMBL476643 | — | — | 2 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457614 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL457614 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL104519 | — | IC50 | = | 9.977 | nM | 8.00 |
| CHEMBL104519 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL104333 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL104333 | — | IC50 | = | 13.06 | nM | 7.88 |
| CHEMBL104279 | — | IC50 | = | 36.7 | nM | 7.43 |
| CHEMBL104279 | — | IC50 | = | 36.73 | nM | 7.43 |
| CHEMBL322153 | — | IC50 | = | 46.03 | nM | 7.34 |
| CHEMBL322153 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4798255 | — | IC50 | = | 92.8 | nM | 7.03 |
| CHEMBL4798255 | — | IC50 | = | 92.9 | nM | 7.03 |
| CHEMBL106226 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL106226 | — | IC50 | = | 102.57 | nM | 6.99 |
| CHEMBL321955 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL321955 | — | IC50 | = | 341.98 | nM | 6.47 |
| CHEMBL4788922 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL4788922 | — | IC50 | = | 365.59 | nM | 6.44 |
| CHEMBL4074055 | — | IC50 | = | 887.16 | nM | 6.05 |
| CHEMBL4074055 | — | IC50 | = | 887.0 | nM | 6.05 |
| CHEMBL471375 | — | IC50 | = | 998.0 | nM | 6.00 |
| CHEMBL471375 | — | IC50 | = | 997.7 | nM | 6.00 |
| CHEMBL476643 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL476643 | — | IC50 | = | 2760.58 | nM | 5.56 |