Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4765713

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of TrkA (unknown origin)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

High affinity nerve growth factor receptor (CHEMBL2815)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Indole-like Trk receptor antagonists.
Tammiku-Taul J,Park R,Jaanson K,Luberg K,Dobchev DA,Kananovich D,Noole A,Mandel M,Kaasik A,Lopp M,Timmusk T,Karelson M
Eur J Med Chem (2016) 121 : 541 -552
PubMed 27318978 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 8.01 8.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL104519 1 8.44
CHEMBL104333 1 8.42
CHEMBL104279 1 8.38
CHEMBL4788922 1 8.28
CHEMBL106226 1 8.07
CHEMBL4798255 1 8.04
CHEMBL322153 1 8.00
CHEMBL321955 1 7.95
CHEMBL471375 1 7.59
CHEMBL4074055 1 7.57
CHEMBL476643 1 7.33
CHEMBL382707 1 -
CHEMBL261425 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL104519 IC50 = 3.66 nM 8.44
CHEMBL104333 IC50 = 3.78 nM 8.42
CHEMBL104279 IC50 = 4.17 nM 8.38
CHEMBL4788922 IC50 = 5.22 nM 8.28
CHEMBL106226 IC50 = 8.49 nM 8.07
CHEMBL4798255 IC50 = 9.17 nM 8.04
CHEMBL322153 IC50 = 10.09 nM 8.00
CHEMBL321955 IC50 = 11.14 nM 7.95
CHEMBL471375 IC50 = 25.7 nM 7.59
CHEMBL4074055 IC50 = 27.21 nM 7.57
CHEMBL476643 IC50 = 46.34 nM 7.33
CHEMBL382707 IC50 > 10000.0 nM -
CHEMBL261425 IC50 > 10000.0 nM -