Assay Detail
Binding
CHEMBL4765818
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-fused TrkA (unknown origin) expressed in SF9 cells using H2N-RRRAAAEEIYGEINH2 peptide as substrate preincubated with ATP and Mg and measured by microtiter plate reader analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indole-like Trk receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.99 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176544 | — | — | 1 | 8.70 |
| CHEMBL175321 | — | — | 1 | 8.22 |
| CHEMBL1794058 | GW278681X | — | 1 | 8.22 |
| CHEMBL1794057 | GW284408X | — | 1 | 8.15 |
| CHEMBL1794056 | GW301789X | — | 1 | 8.10 |
| CHEMBL176857 | GW442130X | — | 1 | 8.10 |
| CHEMBL1276446 | — | — | 1 | 8.05 |
| CHEMBL172179 | — | — | 1 | 7.92 |
| CHEMBL369490 | — | — | 1 | 7.21 |
| CHEMBL269850 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176544 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL175321 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1794058 | GW278681X | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1794057 | GW284408X | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1794056 | GW301789X | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL176857 | GW442130X | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1276446 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL172179 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL369490 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL269850 | — | IC50 | = | 63.0 | nM | 7.20 |