Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4767591

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human U-87MG cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-87MG ATCC
Confidence 1 — Organism
Curated By Autocuration

Target

U-87 MG (CHEMBL614247)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors.
Wang R,Yu S,Zhao X,Chen Y,Yang B,Wu T,Hao C,Zhao D,Cheng M
Eur J Med Chem (2020) 188 : 112024 -112024
PubMed 31923858 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.00 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4785582 1 6.80
CHEMBL4797985 1 6.68
CHEMBL4786967 1 6.60
CHEMBL4779569 1 6.52
CHEMBL4800645 1 6.44
CHEMBL4786939 1 6.34
CHEMBL4784230 1 6.19
CHEMBL4791977 1 6.15
CHEMBL4780493 1 5.97
CHEMBL4792743 1 5.91
CHEMBL4778052 1 5.89
CHEMBL4792276 1 5.89
CHEMBL4799952 1 5.83
CHEMBL458997 1 5.78
CHEMBL4789753 1 5.77
CHEMBL4792993 1 5.71
CHEMBL4788576 1 5.69
CHEMBL4786229 1 5.68
CHEMBL4797411 1 5.62
CHEMBL4789212 1 5.45
CHEMBL4787717 1 5.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4785582 IC50 = 160.0 nM 6.80
CHEMBL4797985 IC50 = 210.0 nM 6.68
CHEMBL4786967 IC50 = 250.0 nM 6.60
CHEMBL4779569 IC50 = 300.0 nM 6.52
CHEMBL4800645 IC50 = 360.0 nM 6.44
CHEMBL4786939 IC50 = 460.0 nM 6.34
CHEMBL4784230 IC50 = 650.0 nM 6.19
CHEMBL4791977 IC50 = 710.0 nM 6.15
CHEMBL4780493 IC50 = 1060.0 nM 5.97
CHEMBL4792743 IC50 = 1220.0 nM 5.91
CHEMBL4778052 IC50 = 1300.0 nM 5.89
CHEMBL4792276 IC50 = 1300.0 nM 5.89
CHEMBL4799952 IC50 = 1480.0 nM 5.83
CHEMBL458997 IC50 = 1670.0 nM 5.78
CHEMBL4789753 IC50 = 1710.0 nM 5.77
CHEMBL4792993 IC50 = 1950.0 nM 5.71
CHEMBL4788576 IC50 = 2030.0 nM 5.69
CHEMBL4786229 IC50 = 2090.0 nM 5.68
CHEMBL4797411 IC50 = 2370.0 nM 5.62
CHEMBL4789212 IC50 = 3590.0 nM 5.45
CHEMBL4787717 IC50 = 6400.0 nM 5.19