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Assay Detail

CHEMBL4767683

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human U87MG cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-87MG ATCC
Confidence 1 — Organism
Curated By Autocuration

Target

U-87 MG (CHEMBL614247)
Type CELL-LINE
Organism Homo sapiens

Publication

Efficient identification of novel anti-glioma lead compounds by machine learning models.
Neves BJ,Agnes JP,Gomes MDN,Henriques Donza MR,Gonçalves RM,Delgobo M,Ribeiro de Souza Neto L,Senger MR,Silva-Junior FP,Ferreira SB,Zanotto-Filho A,Andrade CH
Eur J Med Chem (2020) 189 : 111981 -111981
PubMed 31978780 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 4.97 5.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4061960 1 5.48
CHEMBL4103684 1 5.41
CHEMBL4070585 1 5.31
CHEMBL4073310 1 5.28
CHEMBL4100154 1 5.24
CHEMBL4102608 1 5.17
CHEMBL4072698 1 5.02
CHEMBL4793298 1 5.01
CHEMBL4092551 1 5.00
CHEMBL4776452 1 4.98
CHEMBL4799550 1 4.91
CHEMBL1269013 1 4.90
CHEMBL2029363 1 4.87
CHEMBL4068974 1 4.87
CHEMBL4778320 1 4.72
CHEMBL4079425 1 4.49
CHEMBL4059707 1 4.45
CHEMBL4093415 1 4.35
CHEMBL810 TEMOZOLOMIDE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4061960 EC50 = 3300.0 nM 5.48
CHEMBL4103684 EC50 = 3900.0 nM 5.41
CHEMBL4070585 EC50 = 4900.0 nM 5.31
CHEMBL4073310 EC50 = 5200.0 nM 5.28
CHEMBL4100154 EC50 = 5800.0 nM 5.24
CHEMBL4102608 EC50 = 6800.0 nM 5.17
CHEMBL4072698 EC50 = 9500.0 nM 5.02
CHEMBL4793298 EC50 = 9800.0 nM 5.01
CHEMBL4092551 EC50 = 10100.0 nM 5.00
CHEMBL4776452 EC50 = 10500.0 nM 4.98
CHEMBL4799550 EC50 = 12300.0 nM 4.91
CHEMBL1269013 EC50 = 12600.0 nM 4.90
CHEMBL2029363 EC50 = 13400.0 nM 4.87
CHEMBL4068974 EC50 = 13400.0 nM 4.87
CHEMBL4778320 EC50 = 19200.0 nM 4.72
CHEMBL4079425 EC50 = 32300.0 nM 4.49
CHEMBL4059707 EC50 = 35400.0 nM 4.45
CHEMBL4093415 EC50 = 45100.0 nM 4.35
CHEMBL810 TEMOZOLOMIDE EC50 > 200000.0 nM -