Assay Detail
Functional
CHEMBL4767744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against VSVG/wild-type HIV-1 infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HEK293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 61 | 6.11 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 9.15 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.00 |
| CHEMBL4786649 | — | — | 1 | 7.40 |
| CHEMBL4789248 | — | — | 1 | 7.22 |
| CHEMBL4788219 | — | — | 1 | 6.89 |
| CHEMBL4777503 | — | — | 1 | 6.54 |
| CHEMBL4789780 | — | — | 1 | 6.48 |
| CHEMBL4794839 | — | — | 1 | 6.28 |
| CHEMBL4796981 | — | — | 1 | 6.20 |
| CHEMBL4777692 | — | — | 1 | 6.19 |
| CHEMBL4781358 | — | — | 1 | 6.18 |
| CHEMBL4787089 | — | — | 1 | 6.07 |
| CHEMBL4780164 | — | — | 1 | 5.99 |
| CHEMBL4784657 | — | — | 1 | 5.71 |
| CHEMBL4776779 | — | — | 1 | 5.70 |
| CHEMBL4784960 | — | — | 1 | 5.50 |
| CHEMBL4782177 | — | — | 1 | 5.48 |
| CHEMBL4787214 | — | — | 1 | 5.48 |
| CHEMBL4792750 | — | — | 1 | 5.47 |
| CHEMBL4788653 | — | — | 1 | 5.37 |
| CHEMBL4799554 | — | — | 1 | 5.36 |
| CHEMBL4787040 | — | — | 1 | 5.36 |
| CHEMBL4800616 | — | — | 1 | 5.30 |
| CHEMBL4796340 | — | — | 1 | 5.26 |
| CHEMBL4781771 | — | — | 1 | 5.24 |
| CHEMBL4792436 | — | — | 1 | 5.17 |
| CHEMBL4784334 | — | — | 1 | 5.07 |
| CHEMBL4789119 | — | — | 1 | - |
| CHEMBL4778173 | — | — | 1 | - |
| CHEMBL4797250 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4786649 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4789248 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4788219 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4777503 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4789780 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4794839 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4796981 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4777692 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4781358 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4787089 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4780164 | — | EC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4784657 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4776779 | — | EC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL4784960 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4782177 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4787214 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4792750 | — | EC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL4788653 | — | EC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL4799554 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4787040 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4800616 | — | EC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL4796340 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4781771 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4792436 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4784334 | — | EC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL4782484 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4778920 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4787571 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4793112 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4799624 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4792341 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4781166 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4800598 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4786905 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4789511 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4777991 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4779160 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4792650 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4794221 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4793604 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4778907 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4799319 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4784928 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4786349 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4782421 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4797250 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4778173 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4789119 | — | EC50 | > | 10000.0 | nM | - |