Assay Detail
Functional
CHEMBL4767756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against VSVG/HIV-1 harboring reverse transcriptase Y181C mutant infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HEK293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.62 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.70 |
| CHEMBL4786649 | — | — | 1 | 7.40 |
| CHEMBL4789248 | — | — | 1 | 6.75 |
| CHEMBL4777503 | — | — | 1 | 5.67 |
| CHEMBL4792750 | — | — | 1 | 5.62 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4786649 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4789248 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4777503 | — | EC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL4792750 | — | EC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 2580.0 | nM | 5.59 |