Assay Detail
Binding
CHEMBL4767807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human NOD2 expressed in HEK293 cells assessed as reduction in MDP-induced NF-kappaB activation preincubated for 1 hr followed by MDP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleotide-binding oligomerization domain-containing protein 2 (CHEMBL1293266) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural features and functional activities of benzimidazoles as NOD2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.10 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4778195 | — | — | 1 | 6.20 |
| CHEMBL4795343 | — | — | 1 | 5.32 |
| CHEMBL4795701 | — | — | 1 | 5.29 |
| CHEMBL4792847 | — | — | 1 | 5.29 |
| CHEMBL4792350 | — | — | 1 | 5.28 |
| CHEMBL4793309 | — | — | 1 | 5.24 |
| CHEMBL3321852 | — | — | 1 | 5.21 |
| CHEMBL4791327 | — | — | 1 | 5.21 |
| CHEMBL4778560 | — | — | 1 | 5.06 |
| CHEMBL4795393 | — | — | 1 | 4.97 |
| CHEMBL4778513 | — | — | 1 | 4.79 |
| CHEMBL4800550 | — | — | 1 | 4.64 |
| CHEMBL4781211 | — | — | 1 | 4.59 |
| CHEMBL1412853 | — | — | 1 | 4.26 |
| CHEMBL4793456 | — | — | 1 | - |
| CHEMBL4784164 | — | — | 1 | - |
| CHEMBL4793193 | — | — | 1 | - |
| CHEMBL4794455 | — | — | 1 | - |
| CHEMBL4792755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778195 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4795343 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL4795701 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL4792847 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL4792350 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4793309 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3321852 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4791327 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4778560 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4795393 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4778513 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL4800550 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL4781211 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL1412853 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL4793456 | — | IC50 | - | — | - | |
| CHEMBL4784164 | — | IC50 | - | — | - | |
| CHEMBL4793193 | — | IC50 | - | — | - | |
| CHEMBL4794455 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4792755 | — | IC50 | - | — | - |