Assay Detail
Functional
CHEMBL4768024
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Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability by MTS assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of N-substituted tetrahydropteroate analogs as non-classical antifolates against cobalamin-dependent methionine synthase and potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.89 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.64 |
| CHEMBL4776344 | — | — | 1 | 6.70 |
| CHEMBL4793044 | — | — | 1 | 6.62 |
| CHEMBL4777807 | — | — | 1 | 6.50 |
| CHEMBL4787377 | — | — | 1 | 6.41 |
| CHEMBL4796741 | — | — | 1 | 6.34 |
| CHEMBL4794524 | — | — | 1 | 6.29 |
| CHEMBL4778495 | — | — | 1 | 6.28 |
| CHEMBL4798785 | — | — | 1 | 6.20 |
| CHEMBL4794744 | — | — | 1 | 6.20 |
| CHEMBL4789573 | — | — | 1 | 6.10 |
| CHEMBL4791051 | — | — | 1 | 6.02 |
| CHEMBL4782321 | — | — | 1 | 5.98 |
| CHEMBL4795611 | — | — | 1 | 5.80 |
| CHEMBL4793123 | — | — | 1 | 5.78 |
| CHEMBL4794394 | — | — | 1 | 5.62 |
| CHEMBL4788657 | — | — | 1 | 5.47 |
| CHEMBL4781661 | — | — | 1 | 5.00 |
| CHEMBL4792336 | — | — | 1 | 4.91 |
| CHEMBL4799637 | — | — | 1 | 4.66 |
| CHEMBL4786618 | — | — | 1 | 4.61 |
| CHEMBL4798756 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4776344 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4793044 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4777807 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4787377 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4796741 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4794524 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4778495 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4798785 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4794744 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4789573 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4791051 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4782321 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4795611 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4793123 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL4794394 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL4788657 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL4781661 | — | IC50 | = | 9930.0 | nM | 5.00 |
| CHEMBL4792336 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4799637 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL4786618 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL4798756 | — | IC50 | = | 34000.0 | nM | 4.47 |