Assay Detail
Functional
CHEMBL4768136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3 Env-deficient pseudotype virus infected in human U87/CD4/CCR5 cells assessed by reduction in viral production in late stage measured after 48 hrs by luciferase activity based single-round infection assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | U87/CD4/CCR5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.57 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229713 | — | — | 1 | 6.64 |
| CHEMBL4777603 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229713 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4777603 | — | IC50 | = | 320.0 | nM | 6.50 |