Assay Detail
Functional
CHEMBL4768319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus (A/Duck/Guangdong/674/2014 (H5N6)) group-2 infected in chicken embryo fibroblast assessed as reduction in viral infection preincubated for 1 hrs followed by fibroblast infection and measured after 72 hrs by hemagglutination titre method
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.58 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.01 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.01 |
| CHEMBL4788464 | — | — | 1 | 6.10 |
| CHEMBL4781521 | — | — | 1 | 5.70 |
| CHEMBL4787338 | — | — | 1 | 5.67 |
| CHEMBL4793260 | — | — | 1 | 5.67 |
| CHEMBL4799325 | — | — | 1 | 5.62 |
| CHEMBL4780571 | — | — | 1 | 5.58 |
| CHEMBL4781630 | — | — | 1 | 5.56 |
| CHEMBL4798489 | — | — | 1 | 5.52 |
| CHEMBL4784077 | — | — | 1 | 5.52 |
| CHEMBL4785103 | — | — | 1 | 5.51 |
| CHEMBL4797291 | — | — | 1 | 5.51 |
| CHEMBL4800100 | — | — | 1 | 5.50 |
| CHEMBL4795384 | — | — | 1 | 5.49 |
| CHEMBL4788550 | — | — | 1 | 5.45 |
| CHEMBL4784537 | — | — | 1 | 5.41 |
| CHEMBL4786784 | — | — | 1 | 5.41 |
| CHEMBL4788789 | — | — | 1 | 5.39 |
| CHEMBL4778610 | — | — | 1 | 5.37 |
| CHEMBL4793273 | — | — | 1 | 5.35 |
| CHEMBL4780411 | — | — | 1 | 5.34 |
| CHEMBL4781455 | — | — | 1 | 5.26 |
| CHEMBL4788913 | — | — | 1 | 5.26 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.17 |
| CHEMBL4778066 | — | — | 1 | 5.17 |
| CHEMBL4792112 | — | — | 1 | 5.15 |
| CHEMBL4800348 | — | — | 1 | - |
| CHEMBL4787181 | — | — | 1 | - |
| CHEMBL4786435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4788464 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4781521 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4787338 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4793260 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4799325 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL4780571 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL4781630 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4798489 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4784077 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4797291 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4785103 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4800100 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4795384 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL4788550 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL4784537 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL4786784 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL4788789 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL4778610 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL4793273 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL4780411 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL4788913 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4781455 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL1643 | RIBAVIRIN | IC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL4778066 | — | IC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL4792112 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL4798296 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4796654 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4276887 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4781716 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4795762 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4788112 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4799929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4797961 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4777490 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4783562 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4779927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4794452 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4786435 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4787181 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4800348 | — | IC50 | > | 10000.0 | nM | - |