Assay Detail
Binding
CHEMBL4768523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant lysosomal GCase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 45 mins followed by substrate addition and measured after 30 mins by fluorescence spectrophotometric assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.31 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792854 | — | — | 1 | 6.60 |
| CHEMBL4783905 | — | — | 1 | 5.96 |
| CHEMBL4793095 | — | — | 1 | 5.89 |
| CHEMBL4791125 | — | — | 1 | 5.54 |
| CHEMBL4779198 | — | — | 1 | 5.33 |
| CHEMBL4782789 | — | — | 1 | 5.32 |
| CHEMBL4793871 | — | — | 1 | 5.16 |
| CHEMBL4218664 | — | — | 1 | 4.51 |
| CHEMBL4786169 | — | — | 1 | 4.42 |
| CHEMBL4214414 | — | — | 1 | 4.41 |
| CHEMBL4795488 | — | — | 1 | - |
| CHEMBL4779093 | — | — | 1 | - |
| CHEMBL4778683 | — | — | 1 | - |
| CHEMBL4794112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792854 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4783905 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4793095 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4791125 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4779198 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4782789 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4793871 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4218664 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4786169 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4214414 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4795488 | — | IC50 | = | 333000.0 | nM | - |
| CHEMBL4779093 | — | IC50 | = | 168000.0 | nM | - |
| CHEMBL4778683 | — | IC50 | = | 247000.0 | nM | - |
| CHEMBL4794112 | — | IC50 | = | 725000.0 | nM | - |