Assay Detail
Functional
CHEMBL4768536
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Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.15 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788954 | — | — | 1 | 5.68 |
| CHEMBL4792567 | — | — | 1 | 5.58 |
| CHEMBL4777182 | — | — | 1 | 5.57 |
| CHEMBL4786063 | — | — | 1 | 5.57 |
| CHEMBL4782066 | — | — | 1 | 5.54 |
| CHEMBL4786350 | — | — | 1 | 5.41 |
| CHEMBL4776599 | — | — | 1 | 5.39 |
| CHEMBL4786031 | — | — | 1 | 5.39 |
| CHEMBL4776328 | — | — | 1 | 5.38 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.31 |
| CHEMBL4799886 | — | — | 1 | 5.12 |
| CHEMBL4792705 | — | — | 1 | 5.12 |
| CHEMBL4776974 | — | — | 1 | 5.12 |
| CHEMBL4790137 | — | — | 1 | 5.09 |
| CHEMBL4788942 | — | — | 1 | 5.02 |
| CHEMBL4782327 | — | — | 1 | 4.99 |
| CHEMBL4782988 | — | — | 1 | 4.97 |
| CHEMBL4792025 | — | — | 1 | 4.91 |
| CHEMBL4793650 | — | — | 1 | 4.84 |
| CHEMBL4797623 | — | — | 1 | 4.63 |
| CHEMBL4792980 | — | — | 1 | 4.38 |
| CHEMBL4784481 | — | — | 1 | 4.32 |
| CHEMBL4779831 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788954 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4792567 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4777182 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4786063 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4782066 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4786350 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4776599 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4786031 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4776328 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4799886 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4792705 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4776974 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4790137 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4788942 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4782327 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4782988 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4792025 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4793650 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4797623 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL4792980 | — | IC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL4784481 | — | IC50 | = | 47400.0 | nM | 4.32 |
| CHEMBL4779831 | — | IC50 | > | 50000.0 | nM | - |