Assay Detail
Functional
CHEMBL4768586
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Antiproliferative activity against human U-87 MG cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.49 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776781 | — | — | 1 | 7.31 |
| CHEMBL4781009 | — | — | 1 | 7.19 |
| CHEMBL4778367 | — | — | 1 | 7.07 |
| CHEMBL4786042 | — | — | 1 | 6.91 |
| CHEMBL4792101 | — | — | 1 | 6.78 |
| CHEMBL4794123 | — | — | 1 | 6.73 |
| CHEMBL4784940 | — | — | 1 | 6.60 |
| CHEMBL4783539 | — | — | 1 | 6.54 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.46 |
| CHEMBL4782575 | — | — | 1 | 6.42 |
| CHEMBL4781277 | — | — | 1 | 6.38 |
| CHEMBL4785079 | — | — | 1 | 6.27 |
| CHEMBL4780277 | — | — | 1 | 6.27 |
| CHEMBL4777368 | — | — | 1 | 6.23 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 6.15 |
| CHEMBL4779845 | — | — | 1 | 6.14 |
| CHEMBL4785811 | — | — | 1 | 5.90 |
| CHEMBL4791259 | — | — | 1 | 5.43 |
| CHEMBL4792839 | — | — | 1 | - |
| CHEMBL4787909 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776781 | — | IC50 | = | 49.3 | nM | 7.31 |
| CHEMBL4781009 | — | IC50 | = | 64.8 | nM | 7.19 |
| CHEMBL4778367 | — | IC50 | = | 84.6 | nM | 7.07 |
| CHEMBL4786042 | — | IC50 | = | 122.5 | nM | 6.91 |
| CHEMBL4792101 | — | IC50 | = | 164.9 | nM | 6.78 |
| CHEMBL4794123 | — | IC50 | = | 184.3 | nM | 6.73 |
| CHEMBL4784940 | — | IC50 | = | 248.6 | nM | 6.60 |
| CHEMBL4783539 | — | IC50 | = | 290.6 | nM | 6.54 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 345.2 | nM | 6.46 |
| CHEMBL4782575 | — | IC50 | = | 379.5 | nM | 6.42 |
| CHEMBL4781277 | — | IC50 | = | 412.4 | nM | 6.38 |
| CHEMBL4785079 | — | IC50 | = | 539.3 | nM | 6.27 |
| CHEMBL4780277 | — | IC50 | = | 536.2 | nM | 6.27 |
| CHEMBL4777368 | — | IC50 | = | 585.1 | nM | 6.23 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 706.0 | nM | 6.15 |
| CHEMBL4779845 | — | IC50 | = | 718.9 | nM | 6.14 |
| CHEMBL4785811 | — | IC50 | = | 1262.0 | nM | 5.90 |
| CHEMBL4791259 | — | IC50 | = | 3725.0 | nM | 5.43 |
| CHEMBL4792839 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4787909 | — | IC50 | > | 10000.0 | nM | - |