Assay Detail
Binding
CHEMBL4768630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK7/cyclin H (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 7/ cyclin H (CHEMBL2111288) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.50 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4778367 | — | — | 1 | 7.02 |
| CHEMBL4776781 | — | — | 1 | 6.69 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 5.80 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778367 | — | IC50 | = | 94.7 | nM | 7.02 |
| CHEMBL4776781 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 1596.0 | nM | 5.80 |
| CHEMBL189963 | PALBOCICLIB | IC50 | > | 3333.0 | nM | - |