Assay Detail
ADMET
CHEMBL4768638
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Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.51 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104255 | FLAVOKAWAIN B | — | 1 | 4.58 |
| CHEMBL260597 | — | — | 1 | 4.53 |
| CHEMBL4780658 | — | — | 1 | 4.51 |
| CHEMBL406837 | — | — | 1 | 4.47 |
| CHEMBL4790963 | — | — | 1 | 4.47 |
| CHEMBL610055 | — | — | 1 | - |
| CHEMBL4791916 | — | — | 1 | - |
| CHEMBL4791157 | — | — | 1 | - |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104255 | FLAVOKAWAIN B | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL260597 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL4780658 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL406837 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4790963 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL610055 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4791916 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4791157 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL151 | LUTEOLIN | IC50 | > | 40000.0 | nM | - |