Assay Detail
Functional
CHEMBL4768655
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Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.45 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59026 | — | — | 1 | 7.48 |
| CHEMBL253679 | — | — | 1 | 6.22 |
| CHEMBL276828 | — | — | 1 | 6.16 |
| CHEMBL253467 | ISOBAVACHALCONE | — | 1 | 5.80 |
| CHEMBL561840 | — | — | 1 | 5.66 |
| CHEMBL448217 | 4-HYDROXYISOLONCHOCARPIN | — | 1 | 5.62 |
| CHEMBL187822 | — | — | 1 | 5.54 |
| CHEMBL4777004 | — | — | 1 | 5.40 |
| CHEMBL194094 | — | — | 1 | 5.38 |
| CHEMBL4796875 | — | — | 1 | 5.24 |
| CHEMBL4073108 | — | — | 1 | 5.19 |
| CHEMBL2227828 | — | — | 1 | 5.15 |
| CHEMBL4790820 | — | — | 1 | 5.12 |
| CHEMBL4783705 | — | — | 1 | 5.11 |
| CHEMBL4792118 | — | — | 1 | 5.02 |
| CHEMBL319911 | — | — | 1 | 5.02 |
| CHEMBL362378 | — | — | 1 | 4.99 |
| CHEMBL115452 | BROUSSOCHALCONE A | — | 1 | 4.95 |
| CHEMBL4791908 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59026 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL253679 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL276828 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL253467 | ISOBAVACHALCONE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL561840 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL448217 | 4-HYDROXYISOLONCHOCARPIN | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL187822 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL4777004 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL194094 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL4796875 | — | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL4073108 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2227828 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4790820 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4783705 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4792118 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL319911 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL362378 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL115452 | BROUSSOCHALCONE A | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4791908 | — | IC50 | = | 38600.0 | nM | 4.41 |