Assay Detail
Binding
CHEMBL4769583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BuchE using butyrylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition by Ellman's method
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-alkylpiperidine carbamates as potential anti-Alzheimer's agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.41 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782422 | — | — | 1 | 7.19 |
| CHEMBL4792208 | — | — | 1 | 6.93 |
| CHEMBL4782697 | — | — | 1 | 6.75 |
| CHEMBL4785480 | — | — | 1 | 6.36 |
| CHEMBL4792506 | — | — | 1 | 6.34 |
| CHEMBL4788813 | — | — | 1 | 6.28 |
| CHEMBL4781081 | — | — | 1 | 6.26 |
| CHEMBL4795569 | — | — | 1 | 6.09 |
| CHEMBL4793387 | — | — | 1 | 5.84 |
| CHEMBL1201092 | RIVASTIGMINE TARTRATE | 4.0 | 1 | 5.84 |
| CHEMBL4783852 | — | — | 1 | 5.76 |
| CHEMBL4800026 | — | — | 1 | 5.49 |
| CHEMBL4800467 | — | — | 1 | 5.35 |
| CHEMBL4794030 | — | — | 1 | 5.18 |
| CHEMBL4792483 | — | — | 1 | 5.14 |
| CHEMBL4792310 | — | — | 1 | 5.03 |
| CHEMBL4786091 | — | — | 1 | 5.01 |
| CHEMBL4793319 | — | — | 1 | 4.94 |
| CHEMBL4779214 | — | — | 1 | 4.84 |
| CHEMBL4779749 | — | — | 1 | 4.75 |
| CHEMBL4799709 | — | — | 1 | 4.74 |
| CHEMBL4791143 | — | — | 1 | 4.72 |
| CHEMBL4782186 | — | — | 1 | 4.68 |
| CHEMBL4792289 | — | — | 1 | 4.61 |
| CHEMBL4783379 | — | — | 1 | 4.53 |
| CHEMBL4785240 | — | — | 1 | 4.39 |
| CHEMBL4799313 | — | — | 1 | 4.34 |
| CHEMBL4780895 | — | — | 1 | 4.07 |
| CHEMBL4782857 | — | — | 1 | - |
| CHEMBL4788729 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782422 | — | IC50 | = | 64.5 | nM | 7.19 |
| CHEMBL4792208 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4782697 | — | IC50 | = | 179.5 | nM | 6.75 |
| CHEMBL4785480 | — | IC50 | = | 442.0 | nM | 6.36 |
| CHEMBL4792506 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4788813 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4781081 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL4795569 | — | IC50 | = | 809.0 | nM | 6.09 |
| CHEMBL4793387 | — | IC50 | = | 1433.0 | nM | 5.84 |
| CHEMBL1201092 | RIVASTIGMINE TARTRATE | IC50 | = | 1439.0 | nM | 5.84 |
| CHEMBL4783852 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4800026 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL4800467 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL4794030 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL4792483 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL4792310 | — | IC50 | = | 9390.0 | nM | 5.03 |
| CHEMBL4786091 | — | IC50 | = | 9690.0 | nM | 5.01 |
| CHEMBL4793319 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4779214 | — | IC50 | = | 14380.0 | nM | 4.84 |
| CHEMBL4779749 | — | IC50 | = | 17750.0 | nM | 4.75 |
| CHEMBL4799709 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4791143 | — | IC50 | = | 19060.0 | nM | 4.72 |
| CHEMBL4782186 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4792289 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL4783379 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL4785240 | — | IC50 | = | 40800.0 | nM | 4.39 |
| CHEMBL4799313 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4780895 | — | IC50 | = | 84500.0 | nM | 4.07 |
| CHEMBL4776331 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4789240 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4786153 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4787011 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4777039 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4792634 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4798907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4798315 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1201142 | RASAGILINE MESYLATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL4792299 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4789292 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4780248 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4780765 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4796237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1504199 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4529341 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4571402 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4779393 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4796026 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4797900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4788729 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4782857 | — | IC50 | > | 100000.0 | nM | - |