Assay Detail
Binding
CHEMBL4769734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasma AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by Ellman's method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 4.68 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.66 |
| CHEMBL4786060 | — | — | 1 | 5.47 |
| CHEMBL4782029 | — | — | 1 | 5.44 |
| CHEMBL4800092 | — | — | 1 | 4.84 |
| CHEMBL4781245 | — | — | 1 | 4.74 |
| CHEMBL4776389 | — | — | 1 | 4.71 |
| CHEMBL4790454 | — | — | 1 | 4.70 |
| CHEMBL4796328 | — | — | 1 | 4.65 |
| CHEMBL4798408 | — | — | 1 | 4.64 |
| CHEMBL4782574 | — | — | 1 | 4.60 |
| CHEMBL4782256 | — | — | 1 | 4.53 |
| CHEMBL4786386 | — | — | 1 | 4.49 |
| CHEMBL4777782 | — | — | 1 | 4.48 |
| CHEMBL4800589 | — | — | 1 | 4.45 |
| CHEMBL4789608 | — | — | 1 | 4.45 |
| CHEMBL4786300 | — | — | 1 | 4.43 |
| CHEMBL4783315 | — | — | 1 | 4.43 |
| CHEMBL4784248 | — | — | 1 | 4.41 |
| CHEMBL4795221 | — | — | 1 | 4.41 |
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 4.13 |
| CHEMBL4797232 | — | — | 1 | - |
| CHEMBL4780578 | — | — | 1 | - |
| CHEMBL4798858 | — | — | 1 | - |
| CHEMBL4792068 | — | — | 1 | - |
| CHEMBL4798281 | — | — | 1 | - |
| CHEMBL4796660 | — | — | 1 | - |
| CHEMBL4786778 | — | — | 1 | - |
| CHEMBL4785035 | — | — | 1 | - |
| CHEMBL4788937 | — | — | 1 | - |
| CHEMBL4792702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL4786060 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4782029 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4800092 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4781245 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL4776389 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL4790454 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL4796328 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL4798408 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4782574 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4782256 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL4786386 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL4777782 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL4800589 | — | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL4789608 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL4786300 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL4783315 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL4784248 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL4795221 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL549 | CITALOPRAM | IC50 | = | 73300.0 | nM | 4.13 |
| CHEMBL4778249 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4793718 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4785452 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4799265 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4780560 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4792702 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4788937 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4785035 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4786778 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4796660 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4798281 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4792068 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4798858 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4780578 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4797232 | — | IC50 | > | 50000.0 | nM | - |