Assay Detail
Functional
CHEMBL4770079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC9 cells harboring EGFRdel19 mutant assessed as reduction in cell viability measured after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new thieno[3,2-d]pyrimidine derivatives targeting EGFR NSCLCs by the conformation constrained strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.76 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4781497 | — | — | 1 | 5.24 |
| CHEMBL4780855 | — | — | 1 | 4.79 |
| CHEMBL4779681 | — | — | 1 | 4.78 |
| CHEMBL3786343 | OLMUTINIB | 4.0 | 1 | 4.78 |
| CHEMBL4785528 | — | — | 1 | 4.76 |
| CHEMBL4791953 | — | — | 1 | 4.71 |
| CHEMBL4800533 | — | — | 1 | 4.66 |
| CHEMBL4791108 | — | — | 1 | 4.61 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.50 |
| CHEMBL4782898 | — | — | 1 | - |
| CHEMBL4798996 | — | — | 1 | - |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL4794102 | — | — | 1 | - |
| CHEMBL4776694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4781497 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL4780855 | — | IC50 | = | 16020.0 | nM | 4.79 |
| CHEMBL4779681 | — | IC50 | = | 16730.0 | nM | 4.78 |
| CHEMBL3786343 | OLMUTINIB | IC50 | = | 16510.0 | nM | 4.78 |
| CHEMBL4785528 | — | IC50 | = | 17460.0 | nM | 4.76 |
| CHEMBL4791953 | — | IC50 | = | 19330.0 | nM | 4.71 |
| CHEMBL4800533 | — | IC50 | = | 22130.0 | nM | 4.66 |
| CHEMBL4791108 | — | IC50 | = | 24810.0 | nM | 4.61 |
| CHEMBL939 | GEFITINIB | IC50 | = | 31320.0 | nM | 4.50 |
| CHEMBL4782898 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4798996 | — | IC50 | - | — | - | |
| CHEMBL553 | ERLOTINIB | IC50 | > | 50000.0 | nM | - |
| CHEMBL4794102 | — | IC50 | - | — | - | |
| CHEMBL4776694 | — | IC50 | - | — | - |