Assay Detail
Functional
CHEMBL4770226
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Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.29 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.00 |
| CHEMBL4784348 | — | — | 1 | 8.57 |
| CHEMBL1823159 | — | — | 1 | 8.55 |
| CHEMBL4786045 | — | — | 1 | 8.52 |
| CHEMBL4795215 | — | — | 1 | 8.46 |
| CHEMBL522420 | — | — | 1 | 8.46 |
| CHEMBL4782713 | — | — | 1 | 8.25 |
| CHEMBL4795928 | — | — | 1 | 7.44 |
| CHEMBL4786603 | — | — | 1 | 7.38 |
| CHEMBL4791244 | — | — | 1 | 6.63 |
| CHEMBL4798895 | — | — | 1 | 6.54 |
| CHEMBL4795914 | — | — | 1 | 6.47 |
| CHEMBL4776587 | — | — | 1 | 6.38 |
| CHEMBL4790019 | — | — | 1 | 6.38 |
| CHEMBL4794470 | — | — | 1 | 6.37 |
| CHEMBL4794695 | — | — | 1 | 5.31 |
| CHEMBL4798591 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4784348 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1823159 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4786045 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4795215 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL522420 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4782713 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4795928 | — | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL4786603 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL4791244 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4798895 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL4795914 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL4776587 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL4790019 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL4794470 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL4794695 | — | IC50 | = | 4891.0 | nM | 5.31 |
| CHEMBL4798591 | — | IC50 | = | 7056.0 | nM | 5.15 |