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Assay Detail

CHEMBL4770527

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 NL4-3 infected in human TZM-GFP cells assessed as number of GFP positive cells incubated for 48 hrs by imaging reader
ChEMBL ↗
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type TZM
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Chemical profiling of HIV-1 capsid-targeting antiviral PF74.
Wang L,Casey MC,Vernekar SKV,Do HT,Sahani RL,Kirby KA,Du H,Hachiya A,Zhang H,Tedbury PR,Xie J,Sarafianos SG,Wang Z
Eur J Med Chem (2020) 200 : 112427 -112427
PubMed 32438252 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 70 6.27 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4799878 — — 1 6.85
CHEMBL4797441 — — 1 6.82
CHEMBL4779205 — — 1 6.66
CHEMBL4776037 — — 1 6.64
CHEMBL4776960 — — 1 6.64
CHEMBL4793278 — — 1 6.62
CHEMBL4791856 — — 1 6.60
CHEMBL4794062 — — 1 6.60
CHEMBL4787207 — — 1 6.58
CHEMBL4785545 — — 1 6.57
CHEMBL4779184 — — 1 6.55
CHEMBL4798390 — — 1 6.55
CHEMBL4787161 — — 1 6.55
CHEMBL4796120 — — 1 6.54
CHEMBL4794032 — — 1 6.52
CHEMBL4781130 — — 1 6.51
CHEMBL4785926 — — 1 6.51
CHEMBL4792996 — — 1 6.50
CHEMBL4793142 — — 1 6.50
CHEMBL4793281 — — 1 6.50
CHEMBL4779346 — — 1 6.48
CHEMBL4779232 — — 1 6.48
CHEMBL4788139 — — 1 6.44
CHEMBL4783254 — — 1 6.43
CHEMBL4788351 — — 1 6.36
CHEMBL4777466 — — 1 6.35
CHEMBL4796343 — — 1 6.34
CHEMBL4783684 — — 1 6.31
CHEMBL4800199 — — 1 6.25
CHEMBL4782886 — — 1 6.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4799878 — EC50 = 140.0 nM 6.85
CHEMBL4797441 — EC50 = 150.0 nM 6.82
CHEMBL4779205 — EC50 = 220.0 nM 6.66
CHEMBL4776037 — EC50 = 230.0 nM 6.64
CHEMBL4776960 — EC50 = 230.0 nM 6.64
CHEMBL4793278 — EC50 = 240.0 nM 6.62
CHEMBL4791856 — EC50 = 250.0 nM 6.60
CHEMBL4794062 — EC50 = 250.0 nM 6.60
CHEMBL4787207 — EC50 = 260.0 nM 6.58
CHEMBL4785545 — EC50 = 270.0 nM 6.57
CHEMBL4779184 — EC50 = 280.0 nM 6.55
CHEMBL4798390 — EC50 = 280.0 nM 6.55
CHEMBL4787161 — EC50 = 280.0 nM 6.55
CHEMBL4796120 — EC50 = 290.0 nM 6.54
CHEMBL4794032 — EC50 = 300.0 nM 6.52
CHEMBL4781130 — EC50 = 310.0 nM 6.51
CHEMBL4785926 — EC50 = 310.0 nM 6.51
CHEMBL4792996 — EC50 = 320.0 nM 6.50
CHEMBL4793142 — EC50 = 320.0 nM 6.50
CHEMBL4793281 — EC50 = 320.0 nM 6.50
CHEMBL4779346 — EC50 = 330.0 nM 6.48
CHEMBL4779232 — EC50 = 330.0 nM 6.48
CHEMBL4788139 — EC50 = 360.0 nM 6.44
CHEMBL4783254 — EC50 = 370.0 nM 6.43
CHEMBL4788351 — EC50 = 440.0 nM 6.36
CHEMBL4777466 — EC50 = 450.0 nM 6.35
CHEMBL4796343 — EC50 = 460.0 nM 6.34
CHEMBL4783684 — EC50 = 490.0 nM 6.31
CHEMBL4800199 — EC50 = 560.0 nM 6.25
CHEMBL4782886 — EC50 = 580.0 nM 6.24
CHEMBL1229713 — EC50 = 610.0 nM 6.21
CHEMBL4788393 — EC50 = 630.0 nM 6.20
CHEMBL4785478 — EC50 = 630.0 nM 6.20
CHEMBL4785172 — EC50 = 670.0 nM 6.17
CHEMBL4781449 — EC50 = 690.0 nM 6.16
CHEMBL4786518 — EC50 = 840.0 nM 6.08
CHEMBL4787305 — EC50 = 870.0 nM 6.06
CHEMBL4792335 — EC50 = 1200.0 nM 5.92
CHEMBL4788094 — EC50 = 1300.0 nM 5.89
CHEMBL4788416 — EC50 = 1800.0 nM 5.75
CHEMBL4792752 — EC50 = 2000.0 nM 5.70
CHEMBL4797151 — EC50 = 2000.0 nM 5.70
CHEMBL4778374 — EC50 = 3500.0 nM 5.46
CHEMBL4797603 — EC50 = 3700.0 nM 5.43
CHEMBL4791923 — EC50 = 10000.0 nM 5.00
CHEMBL4780259 — EC50 = 11000.0 nM 4.96
CHEMBL4796958 — EC50 > 20000.0 nM -
CHEMBL4788202 — EC50 > 20000.0 nM -
CHEMBL4781394 — EC50 > 20000.0 nM -
CHEMBL4798833 — EC50 > 20000.0 nM -