Assay Detail
Functional
CHEMBL4771187
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Antiproliferative activity against human NCI-H2228 cells measured after 72 hrs by MTT assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2228 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.14 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784566 | — | — | 1 | 5.58 |
| CHEMBL4789065 | — | — | 1 | 5.24 |
| CHEMBL4800643 | — | — | 1 | 5.20 |
| CHEMBL4778510 | — | — | 1 | 5.20 |
| CHEMBL4781471 | — | — | 1 | 5.14 |
| CHEMBL4800474 | — | — | 1 | 5.10 |
| CHEMBL4800586 | — | — | 1 | 5.07 |
| CHEMBL4794349 | — | — | 1 | 5.01 |
| CHEMBL3186509 | — | — | 1 | 4.95 |
| CHEMBL4789070 | — | — | 1 | 4.94 |
| CHEMBL4778764 | — | — | 1 | - |
| CHEMBL4779021 | — | — | 1 | - |
| CHEMBL4780782 | — | — | 1 | - |
| CHEMBL4776130 | — | — | 1 | - |
| CHEMBL4797128 | — | — | 1 | - |
| CHEMBL4781407 | — | — | 1 | - |
| CHEMBL4791877 | — | — | 1 | - |
| CHEMBL4783040 | — | — | 1 | - |
| CHEMBL4788199 | — | — | 1 | - |
| CHEMBL4798227 | — | — | 1 | - |
| CHEMBL4782735 | — | — | 1 | - |
| CHEMBL4776428 | — | — | 1 | - |
| CHEMBL3828074 | ZIRITAXESTAT | 3.0 | 1 | - |
| CHEMBL4789626 | — | — | 1 | - |
| CHEMBL4783483 | — | — | 1 | - |
| CHEMBL4797813 | — | — | 1 | - |
| CHEMBL4789996 | — | — | 1 | - |
| CHEMBL4783759 | — | — | 1 | - |
| CHEMBL4789880 | — | — | 1 | - |
| CHEMBL4780733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784566 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4789065 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL4778510 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL4800643 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL4781471 | — | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL4800474 | — | IC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL4800586 | — | IC50 | = | 8510.0 | nM | 5.07 |
| CHEMBL4794349 | — | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL3186509 | — | IC50 | = | 11270.0 | nM | 4.95 |
| CHEMBL4789070 | — | IC50 | = | 11530.0 | nM | 4.94 |
| CHEMBL4781407 | — | IC50 | - | — | - | |
| CHEMBL4786412 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4791877 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4783040 | — | IC50 | - | — | - | |
| CHEMBL4788199 | — | IC50 | - | — | - | |
| CHEMBL4798227 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4778551 | — | IC50 | - | — | - | |
| CHEMBL4778972 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4776596 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4778480 | — | IC50 | - | — | - | |
| CHEMBL4788333 | — | IC50 | - | — | - | |
| CHEMBL4782134 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4786557 | — | IC50 | - | — | - | |
| CHEMBL4794345 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4798803 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4797128 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4776130 | — | IC50 | - | — | - | |
| CHEMBL4780782 | — | IC50 | - | — | - | |
| CHEMBL4779021 | — | IC50 | - | — | - | |
| CHEMBL4778764 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4782735 | — | IC50 | - | — | - | |
| CHEMBL4776428 | — | IC50 | - | — | - | |
| CHEMBL3828074 | ZIRITAXESTAT | IC50 | > | 15000.0 | nM | - |
| CHEMBL4789626 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4783483 | — | IC50 | - | — | - | |
| CHEMBL4797813 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4789996 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4783759 | — | IC50 | - | — | - | |
| CHEMBL4789880 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4780733 | — | IC50 | > | 15000.0 | nM | - |