Assay Detail
Binding
CHEMBL4771351
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Inhibition of human JNK3 after 40 mins by [gamma-33ATP] radiometric assay relative to control
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.00 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7064 | — | — | 1 | 7.05 |
| CHEMBL4795574 | — | — | 1 | 6.72 |
| CHEMBL4531109 | — | — | 1 | 6.60 |
| CHEMBL4788894 | — | — | 1 | 6.50 |
| CHEMBL4777530 | — | — | 1 | 6.43 |
| CHEMBL4782208 | — | — | 1 | 6.39 |
| CHEMBL4782076 | — | — | 1 | 6.37 |
| CHEMBL4800639 | — | — | 1 | 6.22 |
| CHEMBL4799531 | — | — | 1 | 5.88 |
| CHEMBL4785607 | — | — | 1 | 5.84 |
| CHEMBL4794035 | — | — | 1 | 5.78 |
| CHEMBL4780101 | — | — | 1 | 5.76 |
| CHEMBL4789089 | — | — | 1 | 5.46 |
| CHEMBL4793426 | — | — | 1 | 5.32 |
| CHEMBL4794586 | — | — | 1 | 5.29 |
| CHEMBL4781949 | — | — | 1 | 5.25 |
| CHEMBL4776996 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7064 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4795574 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4531109 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4788894 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4777530 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4782208 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4782076 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4800639 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4799531 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4785607 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4794035 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4780101 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4789089 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL4793426 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL4794586 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL4781949 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4776996 | — | IC50 | = | 7370.0 | nM | 5.13 |