Assay Detail
Binding
CHEMBL4771364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human EGFR L858R/T790M mutant GGMEDIYFEFMGGKKK as substrate measured after 40 mins in presence of [gamma-33P]ATP by radiometric assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.43 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4531109 | — | — | 1 | 6.43 |
| CHEMBL4795574 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4531109 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4795574 | — | IC50 | > | 10000.0 | nM | - |