Assay Detail
Binding
CHEMBL4771399
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Inhibition of HDAC10 (unknown origin)
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.15 | 9.30 |
| Ki | 1 | 5.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 9.30 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.00 |
| CHEMBL2103863 | ABEXINOSTAT | 3.0 | 1 | 7.28 |
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | 7.00 |
| CHEMBL3110004 | — | — | 1 | 5.70 |
| CHEMBL4777961 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105763 | QUISINOSTAT | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2103863 | ABEXINOSTAT | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3110004 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4777961 | — | IC50 | > | 10000.0 | nM | - |