Assay Detail
Functional
CHEMBL4772196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SK-BR-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, structure and anticancer activity of new geldanamycin amine analogs containing C(17)- or C(20)- flexible and rigid arms as well as closed or open ansa-bridges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.81 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.42 |
| CHEMBL4788059 | — | — | 1 | 7.11 |
| CHEMBL4799459 | — | — | 1 | 6.23 |
| CHEMBL267792 | REBLASTATIN | — | 1 | 6.22 |
| CHEMBL4789807 | — | — | 1 | 6.15 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.06 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 6.06 |
| CHEMBL4776995 | — | — | 1 | 6.03 |
| CHEMBL4798470 | — | — | 1 | 5.99 |
| CHEMBL4795779 | — | — | 1 | 5.99 |
| CHEMBL126986 | — | — | 1 | 5.95 |
| CHEMBL4794622 | — | — | 1 | 5.86 |
| CHEMBL4796409 | — | — | 1 | 5.80 |
| CHEMBL4797303 | — | — | 1 | 5.79 |
| CHEMBL4778032 | — | — | 1 | 5.75 |
| CHEMBL4795680 | — | — | 1 | 5.74 |
| CHEMBL4776084 | — | — | 1 | 5.69 |
| CHEMBL4799181 | — | — | 1 | 5.69 |
| CHEMBL4789835 | — | — | 1 | 5.69 |
| CHEMBL4777420 | — | — | 1 | 5.69 |
| CHEMBL4787237 | — | — | 1 | 5.68 |
| CHEMBL4790976 | — | — | 1 | 5.68 |
| CHEMBL4777034 | — | — | 1 | 5.68 |
| CHEMBL4798246 | — | — | 1 | 5.66 |
| CHEMBL4777512 | — | — | 1 | 5.61 |
| CHEMBL4794663 | — | — | 1 | 5.58 |
| CHEMBL4799122 | — | — | 1 | 5.47 |
| CHEMBL4794124 | — | — | 1 | 5.42 |
| CHEMBL4784511 | — | — | 1 | 5.38 |
| CHEMBL339505 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4788059 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4799459 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL267792 | REBLASTATIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4789807 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL803 | CYTARABINE | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4776995 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4798470 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4795779 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL126986 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4794622 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4796409 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4797303 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4778032 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4795680 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL4777420 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4799181 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4776084 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4789835 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4787237 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4790976 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL4777034 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL4798246 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4777512 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4794663 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL4799122 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL4794124 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL4784511 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL339505 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL4777808 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL4794792 | — | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL4787561 | — | IC50 | = | 11950.0 | nM | 4.92 |
| CHEMBL4776893 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL4798199 | — | IC50 | = | 1139000.0 | nM | - |