Assay Detail
Functional
CHEMBL4772197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, structure and anticancer activity of new geldanamycin amine analogs containing C(17)- or C(20)- flexible and rigid arms as well as closed or open ansa-bridges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.76 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788059 | — | — | 1 | 7.08 |
| CHEMBL267792 | REBLASTATIN | — | 1 | 6.90 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.66 |
| CHEMBL4799459 | — | — | 1 | 6.26 |
| CHEMBL4789807 | — | — | 1 | 6.18 |
| CHEMBL4776995 | — | — | 1 | 6.13 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 6.03 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.00 |
| CHEMBL4794622 | — | — | 1 | 5.96 |
| CHEMBL126986 | — | — | 1 | 5.96 |
| CHEMBL4795680 | — | — | 1 | 5.87 |
| CHEMBL4799181 | — | — | 1 | 5.81 |
| CHEMBL4797303 | — | — | 1 | 5.80 |
| CHEMBL4798470 | — | — | 1 | 5.78 |
| CHEMBL4795779 | — | — | 1 | 5.76 |
| CHEMBL4778032 | — | — | 1 | 5.73 |
| CHEMBL4777420 | — | — | 1 | 5.70 |
| CHEMBL4777512 | — | — | 1 | 5.69 |
| CHEMBL4777034 | — | — | 1 | 5.66 |
| CHEMBL4790976 | — | — | 1 | 5.61 |
| CHEMBL4798246 | — | — | 1 | 5.60 |
| CHEMBL4789835 | — | — | 1 | 5.60 |
| CHEMBL4787237 | — | — | 1 | 5.58 |
| CHEMBL4794663 | — | — | 1 | 5.55 |
| CHEMBL4776084 | — | — | 1 | 5.55 |
| CHEMBL4776893 | — | — | 1 | 5.53 |
| CHEMBL4799122 | — | — | 1 | 5.52 |
| CHEMBL4794124 | — | — | 1 | 5.50 |
| CHEMBL339505 | — | — | 1 | 5.38 |
| CHEMBL4784511 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788059 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL267792 | REBLASTATIN | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4799459 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4789807 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4776995 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL803 | CYTARABINE | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4794622 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL126986 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4795680 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4799181 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4797303 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4798470 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4795779 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4778032 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4777420 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4777512 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4777034 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4790976 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4798246 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4789835 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL4787237 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4794663 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL4776084 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL4776893 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL4799122 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4794124 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL339505 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL4784511 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL4777808 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4794792 | — | IC50 | = | 9410.0 | nM | 5.03 |
| CHEMBL4798199 | — | IC50 | = | 11860.0 | nM | 4.93 |
| CHEMBL4787561 | — | IC50 | = | 12380.0 | nM | 4.91 |
| CHEMBL4796409 | — | IC50 | = | 136000.0 | nM | - |