Assay Detail
Functional
CHEMBL4772198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, structure and anticancer activity of new geldanamycin amine analogs containing C(17)- or C(20)- flexible and rigid arms as well as closed or open ansa-bridges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.81 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267792 | REBLASTATIN | — | 1 | 7.75 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.21 |
| CHEMBL4788059 | — | — | 1 | 6.72 |
| CHEMBL4799459 | — | — | 1 | 6.24 |
| CHEMBL4789807 | — | — | 1 | 6.22 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 6.14 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.09 |
| CHEMBL4776995 | — | — | 1 | 6.09 |
| CHEMBL4778032 | — | — | 1 | 6.00 |
| CHEMBL4796409 | — | — | 1 | 5.94 |
| CHEMBL4794622 | — | — | 1 | 5.90 |
| CHEMBL126986 | — | — | 1 | 5.86 |
| CHEMBL4798470 | — | — | 1 | 5.83 |
| CHEMBL4795680 | — | — | 1 | 5.82 |
| CHEMBL4797303 | — | — | 1 | 5.78 |
| CHEMBL4795779 | — | — | 1 | 5.78 |
| CHEMBL4777420 | — | — | 1 | 5.75 |
| CHEMBL4799181 | — | — | 1 | 5.74 |
| CHEMBL4789835 | — | — | 1 | 5.71 |
| CHEMBL4798246 | — | — | 1 | 5.70 |
| CHEMBL4787237 | — | — | 1 | 5.67 |
| CHEMBL4777034 | — | — | 1 | 5.65 |
| CHEMBL4794663 | — | — | 1 | 5.63 |
| CHEMBL4776893 | — | — | 1 | 5.63 |
| CHEMBL4777512 | — | — | 1 | 5.56 |
| CHEMBL4776084 | — | — | 1 | 5.56 |
| CHEMBL4790976 | — | — | 1 | 5.51 |
| CHEMBL4799122 | — | — | 1 | 5.49 |
| CHEMBL4794124 | — | — | 1 | 5.48 |
| CHEMBL339505 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267792 | REBLASTATIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4788059 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4799459 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4789807 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL803 | CYTARABINE | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4776995 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4778032 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4796409 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4794622 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL126986 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4798470 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4795680 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4795779 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4797303 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4777420 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4799181 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4789835 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4798246 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL4787237 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL4777034 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4794663 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL4776893 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4777512 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL4776084 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL4790976 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL4799122 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL4794124 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL339505 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL4777808 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL4784511 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL4794792 | — | IC50 | = | 9070.0 | nM | 5.04 |
| CHEMBL4798199 | — | IC50 | = | 11720.0 | nM | 4.93 |
| CHEMBL4787561 | — | IC50 | = | 12960.0 | nM | 4.89 |