Assay Detail
Functional
CHEMBL4772200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, structure and anticancer activity of new geldanamycin amine analogs containing C(17)- or C(20)- flexible and rigid arms as well as closed or open ansa-bridges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.71 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788059 | — | — | 1 | 7.11 |
| CHEMBL4799459 | — | — | 1 | 6.23 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.08 |
| CHEMBL4776995 | — | — | 1 | 6.04 |
| CHEMBL4795779 | — | — | 1 | 6.01 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 6.00 |
| CHEMBL126986 | — | — | 1 | 5.98 |
| CHEMBL4789807 | — | — | 1 | 5.96 |
| CHEMBL4796409 | — | — | 1 | 5.95 |
| CHEMBL4795680 | — | — | 1 | 5.95 |
| CHEMBL4798470 | — | — | 1 | 5.92 |
| CHEMBL4794622 | — | — | 1 | 5.86 |
| CHEMBL4799181 | — | — | 1 | 5.80 |
| CHEMBL4797303 | — | — | 1 | 5.79 |
| CHEMBL4778032 | — | — | 1 | 5.78 |
| CHEMBL4777420 | — | — | 1 | 5.70 |
| CHEMBL4776893 | — | — | 1 | 5.68 |
| CHEMBL4789835 | — | — | 1 | 5.67 |
| CHEMBL4787237 | — | — | 1 | 5.62 |
| CHEMBL4776084 | — | — | 1 | 5.58 |
| CHEMBL4790976 | — | — | 1 | 5.57 |
| CHEMBL4777034 | — | — | 1 | 5.56 |
| CHEMBL4794663 | — | — | 1 | 5.54 |
| CHEMBL4777512 | — | — | 1 | 5.53 |
| CHEMBL4798246 | — | — | 1 | 5.53 |
| CHEMBL4794124 | — | — | 1 | 5.48 |
| CHEMBL4799122 | — | — | 1 | 5.43 |
| CHEMBL4784511 | — | — | 1 | 5.39 |
| CHEMBL4777808 | — | — | 1 | 5.36 |
| CHEMBL339505 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788059 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4799459 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL803 | CYTARABINE | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4776995 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4795779 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL126986 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4789807 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4796409 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4795680 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4798470 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4794622 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4799181 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4797303 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4778032 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4777420 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL4776893 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4789835 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4787237 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL4776084 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL4790976 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL4777034 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL4794663 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL4777512 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL4798246 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL4794124 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL4799122 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL4784511 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL4777808 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL339505 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL4794792 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL4798199 | — | IC50 | = | 11050.0 | nM | 4.96 |
| CHEMBL4787561 | — | IC50 | = | 11450.0 | nM | 4.94 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | > | 10000.0 | nM | - |