Assay Detail
Binding
CHEMBL4772323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Cx43 expressed in Escherichia coli LB2003 cells in medium containing 8 mM K+ and 10 uM IPTG by measuring cell growth after 18 hrs by plate reader
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.01 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794431 | — | — | 1 | 5.51 |
| CHEMBL4793190 | — | — | 1 | 5.39 |
| CHEMBL4778380 | — | — | 1 | 5.26 |
| CHEMBL4784426 | — | — | 1 | 5.21 |
| CHEMBL4790312 | — | — | 1 | 5.21 |
| CHEMBL4799209 | — | — | 1 | 5.07 |
| CHEMBL4776897 | — | — | 1 | 5.05 |
| CHEMBL4785499 | — | — | 1 | 5.05 |
| CHEMBL4777167 | — | — | 1 | 4.77 |
| CHEMBL4780949 | — | — | 1 | 4.75 |
| CHEMBL4777222 | — | — | 1 | 4.58 |
| CHEMBL1384 | KANAMYCIN | 4.0 | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794431 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4793190 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4778380 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4784426 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4790312 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4799209 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4776897 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4785499 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4777167 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4780949 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4777222 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL1384 | KANAMYCIN | IC50 | = | 48000.0 | nM | 4.32 |