Assay Detail
Binding
CHEMBL4772325
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Inhibition of human Cx26 expressed in Escherichia coli LB2003 cells in medium containing 4 mM K+ and 500 uM IPTG by measuring cell growth after 18 hrs by plate reader
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.72 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4780949 | — | — | 1 | 5.22 |
| CHEMBL1384 | KANAMYCIN | 4.0 | 1 | 4.94 |
| CHEMBL4785499 | — | — | 1 | 4.90 |
| CHEMBL4776897 | — | — | 1 | 4.76 |
| CHEMBL4799209 | — | — | 1 | 4.73 |
| CHEMBL4790312 | — | — | 1 | 4.31 |
| CHEMBL4795796 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4780949 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1384 | KANAMYCIN | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4785499 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4776897 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL4799209 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL4790312 | — | IC50 | = | 49400.0 | nM | 4.31 |
| CHEMBL4795796 | — | IC50 | = | 66700.0 | nM | 4.18 |