Assay Detail
Functional
CHEMBL4772617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells transfected with wild type ETV6-NTRK2 (unknown origin) assessed as cell viability measured after 72 hrs by Micro plate reader method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and Structure-Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.22 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792981 | — | — | 1 | 7.66 |
| CHEMBL4785469 | — | — | 1 | 7.47 |
| CHEMBL3889654 | LAROTRECTINIB | 4.0 | 1 | 7.40 |
| CHEMBL4787950 | — | — | 1 | 6.79 |
| CHEMBL4782515 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792981 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4785469 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3889654 | LAROTRECTINIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4787950 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4782515 | — | IC50 | = | 169.0 | nM | 6.77 |