Assay Detail
Binding
CHEMBL4772834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 10 mins followed by substrate addition and measured after 25 min by Coomassie blue staining based SDS-PAGE analysis
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzothiophene-2-carboxamide derivatives as SENPs inhibitors with selectivity within SENPs family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.12 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4791433 | — | — | 1 | 6.25 |
| CHEMBL4776158 | — | — | 1 | 6.16 |
| CHEMBL4792569 | — | — | 1 | 5.92 |
| CHEMBL4780770 | — | — | 1 | 5.85 |
| CHEMBL4780586 | — | — | 1 | 5.80 |
| CHEMBL4796113 | — | — | 1 | 5.66 |
| CHEMBL4778045 | — | — | 1 | 5.64 |
| CHEMBL4783695 | — | — | 1 | 5.62 |
| CHEMBL4793952 | — | — | 1 | 5.60 |
| CHEMBL4791044 | — | — | 1 | 5.46 |
| CHEMBL4796293 | — | — | 1 | 5.46 |
| CHEMBL4789655 | — | — | 1 | 5.41 |
| CHEMBL4791142 | — | — | 1 | 5.33 |
| CHEMBL4778402 | — | — | 1 | 5.32 |
| CHEMBL4785749 | — | — | 1 | 5.31 |
| CHEMBL4792795 | — | — | 1 | 5.30 |
| CHEMBL4785280 | — | — | 1 | 5.29 |
| CHEMBL4800446 | — | — | 1 | 5.27 |
| CHEMBL4789800 | — | — | 1 | 5.23 |
| CHEMBL4780660 | — | — | 1 | 5.23 |
| CHEMBL4790106 | — | — | 1 | 5.21 |
| CHEMBL4786762 | — | — | 1 | 5.19 |
| CHEMBL4780417 | — | — | 1 | 5.17 |
| CHEMBL4783089 | — | — | 1 | 5.16 |
| CHEMBL4780306 | — | — | 1 | 5.13 |
| CHEMBL4784778 | — | — | 1 | 5.13 |
| CHEMBL4778786 | — | — | 1 | 5.11 |
| CHEMBL4798900 | — | — | 1 | 5.10 |
| CHEMBL4788149 | — | — | 1 | 5.09 |
| CHEMBL4792661 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4791433 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4776158 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4792569 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4780770 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4780586 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4796113 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4778045 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4783695 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4793952 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4791044 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4796293 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4789655 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4791142 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4778402 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4785749 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4792795 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4785280 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4800446 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4789800 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4780660 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4790106 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4786762 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4780417 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4783089 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4784778 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4780306 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4778786 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4798900 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4788149 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4792661 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4778697 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4789067 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4788955 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4782207 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4787562 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4792715 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4782296 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4789330 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4776955 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4783015 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4793772 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL4799293 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4787683 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4786976 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL4790058 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL4793738 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL4787085 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL4798491 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL3961988 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4776323 | — | IC50 | = | 34200.0 | nM | 4.47 |