Assay Detail
Binding
CHEMBL4773299
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Inhibition of recombinant human PTP1B using pNPP as substrate measured after 30 mins
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of geniposide derivatives as potent and selective PTPlB inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.51 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294467 | SODIUM VANADATE | — | 1 | 7.34 |
| CHEMBL4788887 | — | — | 1 | 6.46 |
| CHEMBL4786441 | — | — | 1 | 6.42 |
| CHEMBL4798517 | — | — | 1 | 6.40 |
| CHEMBL4800140 | — | — | 1 | 6.39 |
| CHEMBL4788294 | — | — | 1 | 6.37 |
| CHEMBL4785543 | — | — | 1 | 6.17 |
| CHEMBL4793462 | — | — | 1 | 6.12 |
| CHEMBL4787688 | — | — | 1 | 6.00 |
| CHEMBL4782087 | — | — | 1 | 5.98 |
| CHEMBL4782460 | — | — | 1 | 5.57 |
| CHEMBL4781365 | — | — | 1 | 5.24 |
| CHEMBL4781042 | — | — | 1 | 4.88 |
| CHEMBL4778849 | — | — | 1 | 4.75 |
| CHEMBL4777827 | — | — | 1 | 4.74 |
| CHEMBL4800515 | — | — | 1 | 4.68 |
| CHEMBL4786486 | — | — | 1 | 4.66 |
| CHEMBL4776892 | — | — | 1 | 4.60 |
| CHEMBL4788179 | — | — | 1 | 4.39 |
| CHEMBL4792019 | — | — | 1 | 4.29 |
| CHEMBL4780652 | — | — | 1 | 4.19 |
| CHEMBL4793782 | — | — | 1 | - |
| CHEMBL4796676 | — | — | 1 | - |
| CHEMBL459016 | GENIPIN | 3.0 | 1 | - |
| CHEMBL462894 | GENIPOSIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294467 | SODIUM VANADATE | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4788887 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4786441 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4798517 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4800140 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4788294 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4785543 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4793462 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4787688 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4782087 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4782460 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL4781365 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4781042 | — | IC50 | = | 13150.0 | nM | 4.88 |
| CHEMBL4778849 | — | IC50 | = | 17690.0 | nM | 4.75 |
| CHEMBL4777827 | — | IC50 | = | 18270.0 | nM | 4.74 |
| CHEMBL4800515 | — | IC50 | = | 20820.0 | nM | 4.68 |
| CHEMBL4786486 | — | IC50 | = | 21740.0 | nM | 4.66 |
| CHEMBL4776892 | — | IC50 | = | 25230.0 | nM | 4.60 |
| CHEMBL4788179 | — | IC50 | = | 40300.0 | nM | 4.39 |
| CHEMBL4792019 | — | IC50 | = | 50760.0 | nM | 4.29 |
| CHEMBL4780652 | — | IC50 | = | 64740.0 | nM | 4.19 |
| CHEMBL4793782 | — | IC50 | = | 236140.0 | nM | - |
| CHEMBL4796676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL459016 | GENIPIN | IC50 | > | 500000.0 | nM | - |
| CHEMBL462894 | GENIPOSIDE | IC50 | > | 500000.0 | nM | - |