Assay Detail
Binding
CHEMBL4774383
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIRT5 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.56 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46469 | ANTHRALIN | 2.0 | 1 | 7.00 |
| CHEMBL608 | PROBUCOL | 4.0 | 1 | 5.80 |
| CHEMBL4778520 | — | — | 1 | 5.66 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 5.58 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 1 | 5.57 |
| CHEMBL249837 | METHACYCLINE | 4.0 | 1 | 5.44 |
| CHEMBL1201346 | BALSALAZIDE | 4.0 | 1 | 5.41 |
| CHEMBL495067 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46469 | ANTHRALIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL608 | PROBUCOL | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4778520 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL249837 | METHACYCLINE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1201346 | BALSALAZIDE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL495067 | — | IC50 | = | 90000.0 | nM | 4.05 |