Assay Detail
Functional
CHEMBL4774872
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Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Betulinic acid derived amides are highly cytotoxic, apoptotic and selective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.22 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4799690 | — | — | 1 | 5.83 |
| CHEMBL4791537 | — | — | 1 | 5.54 |
| CHEMBL4797234 | — | — | 1 | 5.54 |
| CHEMBL4781944 | — | — | 1 | 5.52 |
| CHEMBL4783710 | — | — | 1 | 5.50 |
| CHEMBL4783810 | — | — | 1 | 5.48 |
| CHEMBL3740744 | — | — | 1 | 5.39 |
| CHEMBL4776257 | — | — | 1 | 5.34 |
| CHEMBL4795748 | — | — | 1 | 5.31 |
| CHEMBL4793256 | — | — | 1 | 5.25 |
| CHEMBL3799289 | — | — | 1 | 4.95 |
| CHEMBL517089 | — | — | 1 | 4.86 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 4.84 |
| CHEMBL4781275 | — | — | 1 | 4.80 |
| CHEMBL312687 | — | — | 1 | 4.72 |
| CHEMBL4788210 | — | — | 1 | 4.65 |
| CHEMBL4796181 | — | — | 1 | - |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
| CHEMBL4783396 | — | — | 1 | - |
| CHEMBL4779279 | — | — | 1 | - |
| CHEMBL4081749 | — | — | 1 | - |
| CHEMBL4794399 | — | — | 1 | - |
| CHEMBL2425316 | — | — | 1 | - |
| CHEMBL80460 | PLATANIC ACID | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4799690 | — | EC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4791537 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4797234 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4781944 | — | EC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4783710 | — | EC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4783810 | — | EC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL3740744 | — | EC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL4776257 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4795748 | — | EC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL4793256 | — | EC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL3799289 | — | EC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL517089 | — | EC50 | = | 13760.0 | nM | 4.86 |
| CHEMBL431525 | BETUNOLIC ACID | EC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL4781275 | — | EC50 | = | 15810.0 | nM | 4.80 |
| CHEMBL312687 | — | EC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4788210 | — | EC50 | = | 22540.0 | nM | 4.65 |
| CHEMBL4796181 | — | EC50 | - | — | - | |
| CHEMBL269277 | BETULINIC ACID | EC50 | > | 30000.0 | nM | - |
| CHEMBL4783396 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4779279 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4081749 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4794399 | — | EC50 | - | — | - | |
| CHEMBL2425316 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL80460 | PLATANIC ACID | EC50 | > | 30000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | EC50 | - | — | - |