Assay Detail
Binding
CHEMBL4775347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I] [NIe75, Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma counting based Cheng-Prusoff equation analysis
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 71 | 7.43 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796315 | — | — | 1 | 9.72 |
| CHEMBL3184840 | — | — | 1 | 9.15 |
| CHEMBL4780368 | — | — | 1 | 9.03 |
| CHEMBL4791583 | — | — | 1 | 8.96 |
| CHEMBL4797921 | — | — | 1 | 8.62 |
| CHEMBL4781348 | — | — | 1 | 8.41 |
| CHEMBL4794333 | — | — | 1 | 8.40 |
| CHEMBL4790636 | — | — | 1 | 8.40 |
| CHEMBL4777690 | — | — | 1 | 8.40 |
| CHEMBL4788436 | — | — | 1 | 8.34 |
| CHEMBL4797169 | — | — | 1 | 8.29 |
| CHEMBL4791398 | — | — | 1 | 8.05 |
| CHEMBL4791473 | — | — | 1 | 8.03 |
| CHEMBL4793361 | — | — | 1 | 7.89 |
| CHEMBL4779171 | — | — | 1 | 7.80 |
| CHEMBL4787249 | — | — | 1 | 7.80 |
| CHEMBL4785339 | — | — | 1 | 7.80 |
| CHEMBL4795334 | — | — | 1 | 7.75 |
| CHEMBL4795339 | — | — | 1 | 7.72 |
| CHEMBL4780010 | — | — | 1 | 7.72 |
| CHEMBL4788480 | — | — | 1 | 7.70 |
| CHEMBL4789289 | — | — | 1 | 7.68 |
| CHEMBL4778604 | — | — | 1 | 7.68 |
| CHEMBL4792840 | — | — | 1 | 7.60 |
| CHEMBL4795922 | — | — | 1 | 7.54 |
| CHEMBL4784932 | — | — | 1 | 7.42 |
| CHEMBL4776332 | — | — | 1 | 7.35 |
| CHEMBL4779853 | — | — | 1 | 7.32 |
| CHEMBL4797849 | — | — | 1 | 7.27 |
| CHEMBL4782415 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796315 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL3184840 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4780368 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL4791583 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4797921 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL4781348 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL4794333 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4790636 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4777690 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4788436 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL4797169 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4791398 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL4791473 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL4793361 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4785339 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4787249 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4779171 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4795334 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL4795339 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL4780010 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL4788480 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4789289 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL4778604 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL4792840 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4795922 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL4784932 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL4776332 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL4779853 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL4797849 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL4782415 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL4799819 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL4785901 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL4798898 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL4798345 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL4792261 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL4786248 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL4776966 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL4787473 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL4792342 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL4780831 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL4789073 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL4785505 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL4781727 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL4799725 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL4787012 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL4791432 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL4791619 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL4795676 | — | Ki | = | 419.0 | nM | 6.38 |
| CHEMBL4784523 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL4777893 | — | Ki | = | 463.0 | nM | 6.33 |