Assay Detail
Binding
CHEMBL4775514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at VDR in human HL-60 cells assessed as induction of cell differentiation of promyelocytes to monocytes after 4 days by NBT reduction assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.51 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776651 | — | — | 1 | 9.28 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.80 |
| CHEMBL4794075 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776651 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4794075 | — | EC50 | = | 36.0 | nM | 7.44 |