Assay Detail
Binding
CHEMBL4775519
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human VDR expressed in African green monkey COS7 cells expressing mouse osteopontin VDRE assessed as induction of receptor transactivation incubated for 16 hrs by luciferase reporter gene assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.92 | 9.62 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794075 | — | — | 2 | 9.62 |
| CHEMBL4776651 | — | — | 2 | 9.00 |
| CHEMBL846 | CALCITRIOL | 4.0 | 2 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794075 | — | EC50 | = | 0.24 | nM | 9.62 |
| CHEMBL4776651 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4776651 | — | Activity | - | — | - | |
| CHEMBL4794075 | — | Activity | - | — | - | |
| CHEMBL846 | CALCITRIOL | Activity | - | — | - |