Assay Detail
Binding
CHEMBL4775524
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human ACMSD using ACMS substrate by spectrometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (CHEMBL4105941) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.21 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.59 |
| CHEMBL284104 | DIPICOLINIC ACID | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | Ki | = | 2560.0 | nM | 5.59 |
| CHEMBL284104 | DIPICOLINIC ACID | Ki | = | 15200.0 | nM | 4.82 |