Assay Detail
Binding
CHEMBL4775525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ACMSD using ACMS substrate by spectrometry
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (CHEMBL4105941) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.06 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796997 | — | — | 1 | 7.11 |
| CHEMBL3126314 | — | — | 1 | 5.88 |
| CHEMBL4798885 | — | — | 1 | 5.51 |
| CHEMBL419420 | — | — | 1 | 5.48 |
| CHEMBL121772 | — | — | 1 | 5.37 |
| CHEMBL4777218 | — | — | 1 | 5.34 |
| CHEMBL102336 | — | — | 1 | 5.05 |
| CHEMBL4786884 | — | — | 1 | 4.96 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 4.87 |
| CHEMBL4790894 | — | — | 1 | 4.87 |
| CHEMBL4245097 | — | — | 1 | 4.70 |
| CHEMBL4777331 | — | — | 1 | 4.57 |
| CHEMBL4797549 | — | — | 1 | 4.43 |
| CHEMBL3244578 | — | — | 1 | 4.36 |
| CHEMBL4777119 | — | — | 1 | 4.32 |
| CHEMBL475848 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796997 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3126314 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4798885 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL419420 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL121772 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL4777218 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL102336 | — | IC50 | = | 8830.0 | nM | 5.05 |
| CHEMBL4786884 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL898 | DIFLUNISAL | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4790894 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4245097 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL4777331 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL4797549 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL3244578 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL4777119 | — | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL475848 | — | IC50 | = | 88000.0 | nM | 4.06 |