Assay Detail
Binding
CHEMBL4775527
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Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 9.21 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4789639 | BMS-986202 | 1.0 | 1 | 9.72 |
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 9.70 |
| CHEMBL4793760 | — | — | 1 | 9.60 |
| CHEMBL4799019 | — | — | 1 | 9.60 |
| CHEMBL4780233 | — | — | 1 | 9.57 |
| CHEMBL4799559 | — | — | 1 | 9.52 |
| CHEMBL4777175 | — | — | 1 | 9.36 |
| CHEMBL4796821 | — | — | 1 | 9.32 |
| CHEMBL4799031 | — | — | 1 | 9.32 |
| CHEMBL4782449 | — | — | 1 | 9.30 |
| CHEMBL4784838 | — | — | 1 | 9.29 |
| CHEMBL4792780 | — | — | 1 | 9.28 |
| CHEMBL4780315 | — | — | 1 | 9.27 |
| CHEMBL4797596 | — | — | 1 | 9.15 |
| CHEMBL4785957 | — | — | 1 | 8.92 |
| CHEMBL4777648 | — | — | 1 | 8.89 |
| CHEMBL4776752 | — | — | 1 | 8.85 |
| CHEMBL4788122 | — | — | 1 | 8.85 |
| CHEMBL4799830 | — | — | 1 | 8.80 |
| CHEMBL4784391 | — | — | 1 | 8.72 |
| CHEMBL4780057 | — | — | 1 | 8.35 |
| CHEMBL4777528 | — | — | 1 | - |
| CHEMBL4785512 | — | — | 1 | - |
| CHEMBL4800399 | — | — | 1 | - |
| CHEMBL4792694 | — | — | 1 | - |
| CHEMBL4789015 | — | — | 1 | - |
| CHEMBL4795231 | — | — | 1 | - |
| CHEMBL4792231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4789639 | BMS-986202 | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4435170 | DEUCRAVACITINIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4793760 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4799019 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4780233 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL4799559 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4777175 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL4796821 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL4799031 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL4782449 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4784838 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4792780 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL4780315 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL4797596 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL4785957 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4777648 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4776752 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4788122 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4799830 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4784391 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4780057 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4777528 | — | IC50 | < | 0.25 | nM | - |
| CHEMBL4785512 | — | IC50 | < | 0.25 | nM | - |
| CHEMBL4800399 | — | IC50 | < | 0.25 | nM | - |
| CHEMBL4792694 | — | IC50 | < | 0.25 | nM | - |
| CHEMBL4789015 | — | IC50 | < | 0.25 | nM | - |
| CHEMBL4795231 | — | IC50 | < | 0.25 | nM | - |
| CHEMBL4792231 | — | IC50 | < | 0.25 | nM | - |