Assay Detail
Binding
CHEMBL4775528
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Inhibition of TYK2 in IFN-alpha stimulated human Kit225 T cells by luciferase reporter gene assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KIT225 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.80 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 8.28 |
| CHEMBL4777528 | — | — | 1 | 8.21 |
| CHEMBL4789015 | — | — | 1 | 8.19 |
| CHEMBL4795231 | — | — | 1 | 8.12 |
| CHEMBL4800399 | — | — | 1 | 8.07 |
| CHEMBL4777175 | — | — | 1 | 8.07 |
| CHEMBL4792231 | — | — | 1 | 8.05 |
| CHEMBL4792780 | — | — | 1 | 8.00 |
| CHEMBL4789639 | BMS-986202 | 1.0 | 1 | 8.00 |
| CHEMBL4792694 | — | — | 1 | 7.96 |
| CHEMBL4796821 | — | — | 1 | 7.92 |
| CHEMBL4799019 | — | — | 1 | 7.89 |
| CHEMBL4785957 | — | — | 1 | 7.89 |
| CHEMBL4799559 | — | — | 1 | 7.85 |
| CHEMBL4785512 | — | — | 1 | 7.85 |
| CHEMBL4797596 | — | — | 1 | 7.80 |
| CHEMBL4793760 | — | — | 1 | 7.77 |
| CHEMBL4799031 | — | — | 1 | 7.77 |
| CHEMBL4784838 | — | — | 1 | 7.75 |
| CHEMBL4777648 | — | — | 1 | 7.70 |
| CHEMBL4782449 | — | — | 1 | 7.54 |
| CHEMBL4780233 | — | — | 1 | 7.54 |
| CHEMBL4780315 | — | — | 1 | 7.52 |
| CHEMBL4784391 | — | — | 1 | 7.50 |
| CHEMBL4799830 | — | — | 1 | 7.39 |
| CHEMBL4776752 | — | — | 1 | 7.30 |
| CHEMBL4780057 | — | — | 1 | 7.17 |
| CHEMBL4788122 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4777528 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4789015 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4795231 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4800399 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4777175 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4792231 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4792780 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4789639 | BMS-986202 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4792694 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4796821 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4799019 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4785957 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4799559 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4785512 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4797596 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4793760 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4799031 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4784838 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4777648 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4782449 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4780233 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4780315 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4784391 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4799830 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4776752 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4780057 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4788122 | — | IC50 | = | 69.0 | nM | 7.16 |