Assay Detail
Binding
CHEMBL4775529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 in human whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.08 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 7.75 |
| CHEMBL4777528 | — | — | 1 | 7.62 |
| CHEMBL4789015 | — | — | 1 | 7.39 |
| CHEMBL4792231 | — | — | 1 | 7.39 |
| CHEMBL4785512 | — | — | 1 | 7.38 |
| CHEMBL4800399 | — | — | 1 | 7.38 |
| CHEMBL4792694 | — | — | 1 | 7.36 |
| CHEMBL4792780 | — | — | 1 | 7.33 |
| CHEMBL4799031 | — | — | 1 | 7.28 |
| CHEMBL4777175 | — | — | 1 | 7.28 |
| CHEMBL4795231 | — | — | 1 | 7.27 |
| CHEMBL4789639 | BMS-986202 | 1.0 | 1 | 7.24 |
| CHEMBL4793760 | — | — | 1 | 7.23 |
| CHEMBL4797596 | — | — | 1 | 7.20 |
| CHEMBL4799559 | — | — | 1 | 7.16 |
| CHEMBL4784838 | — | — | 1 | 7.14 |
| CHEMBL4782449 | — | — | 1 | 7.06 |
| CHEMBL4799019 | — | — | 1 | 7.04 |
| CHEMBL4796821 | — | — | 1 | 6.97 |
| CHEMBL4777648 | — | — | 1 | 6.95 |
| CHEMBL4785957 | — | — | 1 | 6.89 |
| CHEMBL4784391 | — | — | 1 | 6.79 |
| CHEMBL4788122 | — | — | 1 | 6.74 |
| CHEMBL4780057 | — | — | 1 | 6.65 |
| CHEMBL4780233 | — | — | 1 | 6.63 |
| CHEMBL4780315 | — | — | 1 | 6.47 |
| CHEMBL4799830 | — | — | 1 | 6.37 |
| CHEMBL4776752 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4777528 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4789015 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4792231 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4785512 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4800399 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4792694 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4792780 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4799031 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4777175 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4795231 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4789639 | BMS-986202 | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4793760 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4797596 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4799559 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4784838 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4782449 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4799019 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4796821 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4777648 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4785957 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4784391 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4788122 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4780057 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL4780233 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4780315 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL4799830 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4776752 | — | IC50 | = | 461.0 | nM | 6.34 |