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Assay Detail

CHEMBL4775585

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat alpha-2,3-N-ST3GALIII assessed as reduction in sialylated-product formation using Gal-beta1-4Glc and CMP-NeuSAc incubated for 1.5 hrs by reverse-phase HPLC analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis.
Fu CW,Tsai HE,Chen WS,Chang TT,Chen CL,Hsiao PW,Li WS
J Med Chem (2021) 64 : 527 -542
PubMed 33371679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.85 6.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4798770 1 6.11
CHEMBL4785533 1 6.10
CHEMBL3596261 1 6.05
CHEMBL4785375 1 6.00
CHEMBL4795609 1 6.00
CHEMBL4780118 1 5.76
CHEMBL4797481 1 4.92
CHEMBL4790244 1 -
CHEMBL4781666 1 -
CHEMBL4793269 1 -
CHEMBL4786588 1 -
CHEMBL4779174 1 -
CHEMBL4800187 1 -
CHEMBL4797927 1 -
CHEMBL4776137 1 -
CHEMBL4793980 1 -
CHEMBL4777310 1 -
CHEMBL258818 LITHOGLYCOCHOLATE 1 -
CHEMBL511016 SOYASAPONIN I 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4798770 IC50 = 770.0 nM 6.11
CHEMBL4785533 IC50 = 800.0 nM 6.10
CHEMBL3596261 IC50 = 900.0 nM 6.05
CHEMBL4785375 IC50 = 1010.0 nM 6.00
CHEMBL4795609 IC50 = 1000.0 nM 6.00
CHEMBL4780118 IC50 = 1740.0 nM 5.76
CHEMBL4797481 IC50 = 12000.0 nM 4.92
CHEMBL4790244 IC50 - -
CHEMBL4781666 IC50 - -
CHEMBL4793269 IC50 - -
CHEMBL4786588 IC50 - -
CHEMBL4779174 IC50 - -
CHEMBL4800187 IC50 - -
CHEMBL4797927 IC50 - -
CHEMBL4776137 IC50 - -
CHEMBL4793980 IC50 - -
CHEMBL4777310 IC50 - -
CHEMBL258818 LITHOGLYCOCHOLATE IC50 - -
CHEMBL511016 SOYASAPONIN I IC50 - -