Assay Detail
Binding
CHEMBL4775692
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Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.86 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4779359 | — | — | 1 | 7.54 |
| CHEMBL4793924 | — | — | 1 | 7.15 |
| CHEMBL4787790 | — | — | 1 | 6.79 |
| CHEMBL4793441 | — | — | 1 | 6.72 |
| CHEMBL4778232 | — | — | 1 | 5.87 |
| CHEMBL4779860 | — | — | 1 | 5.28 |
| CHEMBL4783333 | — | — | 1 | 5.10 |
| CHEMBL4793685 | — | — | 1 | 4.60 |
| CHEMBL347547 | — | — | 1 | 3.69 |
| CHEMBL4777805 | — | — | 1 | - |
| CHEMBL1507048 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4779359 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4793924 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4787790 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4793441 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4778232 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4779860 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4783333 | — | IC50 | = | 7960.0 | nM | 5.10 |
| CHEMBL4793685 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL347547 | — | IC50 | = | 204000.0 | nM | 3.69 |
| CHEMBL4777805 | — | IC50 | - | — | - | |
| CHEMBL1507048 | — | IC50 | - | — | - |