Assay Detail
Binding
CHEMBL4775807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human TRPV1 expressed in CHO cells assessed as stimulation of calcium uptake by 45Ca2+ uptake assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 7.58 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4789932 | — | — | 1 | 8.55 |
| CHEMBL4789599 | — | — | 1 | 8.51 |
| CHEMBL4787182 | — | — | 1 | 8.24 |
| CHEMBL4776728 | — | — | 1 | 8.02 |
| CHEMBL4800517 | — | — | 1 | 8.02 |
| CHEMBL4785719 | — | — | 1 | 7.88 |
| CHEMBL4797315 | — | — | 1 | 7.81 |
| CHEMBL4776303 | — | — | 1 | 7.38 |
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 7.35 |
| CHEMBL4798242 | — | — | 1 | 7.20 |
| CHEMBL4789711 | — | — | 1 | 7.16 |
| CHEMBL4800225 | — | — | 1 | 7.11 |
| CHEMBL4782252 | — | — | 1 | 7.10 |
| CHEMBL4792255 | — | — | 1 | 6.80 |
| CHEMBL4779603 | — | — | 1 | 6.59 |
| CHEMBL2177429 | — | — | 1 | - |
| CHEMBL4781687 | — | — | 1 | - |
| CHEMBL4783554 | — | — | 1 | - |
| CHEMBL4790740 | — | — | 1 | - |
| CHEMBL4794837 | — | — | 1 | - |
| CHEMBL4782008 | — | — | 1 | - |
| CHEMBL4786158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4789932 | — | EC50 | = | 2.79 | nM | 8.55 |
| CHEMBL4789599 | — | EC50 | = | 3.07 | nM | 8.51 |
| CHEMBL4787182 | — | EC50 | = | 5.81 | nM | 8.24 |
| CHEMBL4776728 | — | EC50 | = | 9.59 | nM | 8.02 |
| CHEMBL4800517 | — | EC50 | = | 9.59 | nM | 8.02 |
| CHEMBL4785719 | — | EC50 | = | 13.2 | nM | 7.88 |
| CHEMBL4797315 | — | EC50 | = | 15.5 | nM | 7.81 |
| CHEMBL4776303 | — | EC50 | = | 41.4 | nM | 7.38 |
| CHEMBL294199 | CAPSAICIN | EC50 | = | 44.8 | nM | 7.35 |
| CHEMBL4798242 | — | EC50 | = | 63.2 | nM | 7.20 |
| CHEMBL4789711 | — | EC50 | = | 69.3 | nM | 7.16 |
| CHEMBL4800225 | — | EC50 | = | 78.6 | nM | 7.11 |
| CHEMBL4782252 | — | EC50 | = | 78.7 | nM | 7.10 |
| CHEMBL4792255 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4779603 | — | EC50 | = | 258.0 | nM | 6.59 |
| CHEMBL2177429 | — | EC50 | - | — | - | |
| CHEMBL4781687 | — | EC50 | - | — | - | |
| CHEMBL4783554 | — | EC50 | - | — | - | |
| CHEMBL4790740 | — | EC50 | - | — | - | |
| CHEMBL4794837 | — | EC50 | - | — | - | |
| CHEMBL4782008 | — | EC50 | - | — | - | |
| CHEMBL4786158 | — | EC50 | - | — | - |