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Assay Detail

CHEMBL4806265

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of casein kinase 1delta (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Casein kinase I isoform delta (CHEMBL2828)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Small molecule inhibitors of cdk12/cdk13
(2019)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.08 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4855324 1 8.40
CHEMBL4849960 1 6.48
CHEMBL4856935 1 6.40
CHEMBL4849684 1 6.38
CHEMBL4868958 1 6.06
CHEMBL4867928 1 5.90
CHEMBL4877117 1 5.53
CHEMBL4847754 1 5.32
CHEMBL4868638 1 5.22
CHEMBL4852083 1 5.07
CHEMBL4856716 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4855324 IC50 = 4.0 nM 8.40
CHEMBL4849960 IC50 = 333.0 nM 6.48
CHEMBL4856935 IC50 = 400.0 nM 6.40
CHEMBL4849684 IC50 = 419.0 nM 6.38
CHEMBL4868958 IC50 = 870.0 nM 6.06
CHEMBL4867928 IC50 = 1257.0 nM 5.90
CHEMBL4877117 IC50 = 2935.0 nM 5.53
CHEMBL4847754 IC50 = 4745.0 nM 5.32
CHEMBL4868638 IC50 = 6065.0 nM 5.22
CHEMBL4852083 IC50 = 8600.0 nM 5.07
CHEMBL4856716 IC50 > 9900.0 nM -