Assay Detail
Binding
CHEMBL4806367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK8/CDK19 in HEK293 cells by NF-kappaB reporter assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
3-amino-4-(4-(4 (dimethylcarbamoyl) phenyl)-1,4-diazepan-1-yl) thieno [2,3-b] pyridine-2-carboxamide for use in cancer therapy and formulations comprising the same
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.69 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2348353 | — | — | 1 | 8.40 |
| CHEMBL2348350 | — | — | 1 | 8.00 |
| CHEMBL2348351 | — | — | 1 | 7.64 |
| CHEMBL2348342 | — | — | 1 | 7.42 |
| CHEMBL2348345 | — | — | 1 | 7.37 |
| CHEMBL2348339 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2348353 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2348350 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2348351 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL2348342 | — | IC50 | = | 37.8 | nM | 7.42 |
| CHEMBL2348345 | — | IC50 | = | 43.1 | nM | 7.37 |
| CHEMBL2348339 | — | IC50 | = | 50.6 | nM | 7.30 |